TY - JOUR AU - Bakht, Jehan AU - Bukhari, Ayesha AU - Iqbal, Arshad AU - Shafi, Mohammad PY - 2021/07/06 Y2 - 2024/03/28 TI - In vitro Antimicrobial Potential of Samples From the Leaves and Fruits of Medicinally Important Melia azedarach: Antimicrobial Activity of Melia azedarach JF - Biological Sciences - PJSIR JA - Pakistan Journal of Scientific & Industrial Research VL - 64 IS - 2 SE - Articles DO - 10.52763/PJSIR.BIOL.SCI.64.2.2021.109.115 UR - https://v2.pjsir.org/index.php/biological-sciences/article/view/2081 SP - 109-115 AB - <p>Different solvent extracted samples obtained from the leaves and fruits of <em>Melia azedarach </em>were investigated for their antibacterial and antifungal activities. All the extracts from both tissues sources showed varying degrees of antimicrobial activities. Ethyl acetate and n-butanol extracts of both tissues inhibited the growth of the tested micro-organisms at all concentrations. N-hexane extracted fractions of the leaves reduced the activity of <em>Bacillus subtilis</em>, <em>Staphylococcus aureus</em>, <em>Escherichia </em><em>coli </em>and <em>Pseudomonas aeruginosa </em>at all concentrations, while no growth inhibition was recorded against <em>Klebsiella pneumonia </em>and <em>Candida albicans</em>. Crude methanolic extract from the leaves tissues showed activity against all the tested microbial species and highest susceptibility was noted against <em>Bacillus subtilis</em>. In case of leaves, the most susceptible bacteria were <em>Bacillus subtilis </em>(gram positive) and <em>Klebsiella pneumonia </em>(gram negative) was the most resistant one. In case of fruits extracts, the most susceptible bacteria were <em>Klebsiella pneumonia </em>(gram negative) and <em>Escherichia coli </em>(gram negative) was the most resistant one.</p><p>&nbsp;</p> ER -