?ANTIPYRETIC AND ANALGESIC ACTIVITY IN CRUDE ETHANOLIC EXTRACT OF CALENDULA OFFICINALIS LINN

Authors

  • Shahna Ahmad Pharmaceutical and Fine Chemicals Research Centre, PCSIR Laboratories Complex, Karachi-75280, Pakistan
  • Shamim Qureshi Pharmaceutical and Fine Chemicals Research Centre, PCSIR Laboratories Complex, Karachi-75280, Pakistan
  • Atiq-ur- Rehman Pharmaceutical and Fine Chemicals Research Centre, PCSIR Laboratories Complex, Karachi-75280, Pakistan
  • Zakir-ur- Rehman Pharmaceutical and Fine Chemicals Research Centre, PCSIR Laboratories Complex, Karachi-75280, Pakistan
  • Yasmeen Badar Pharmaceutical and Fine Chemicals Research Centre, PCSIR Laboratories Complex, Karachi-75280, Pakistan

Keywords:

Calendula officinalis; Antipyretic; Analgesic activity.

Abstract

Crude extractofCalendula officinalis Linn.exhibitedsignificantantipyretic(74.95%inhibition)andanalgesic(27.42%
inhibition) effects at a dose of 300 mg kg' 40 mg kg-'respectively as compared to standard i.e. acetyl salicylic acid
which exhibited 50.5%and 11.3%respectively.Theextract notonlyreversedtheinduced hyperthermiabut also affect
the normothermia in rats. A dose of 20 mgkg' crude extract was found to be equipotent in its analgesic action to 40
mgkg' ofacetyl salicylic acid.The extractwasfoundtobenon-toxic andshowedawidemarginof safetythrough oral
route.

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Published

2000-05-22

How to Cite

Ahmad, S., Qureshi, S., Rehman, A.- ur-., Rehman, Z.- ur-., & Badar, Y. (2000). ?ANTIPYRETIC AND ANALGESIC ACTIVITY IN CRUDE ETHANOLIC EXTRACT OF CALENDULA OFFICINALIS LINN. Biological Sciences - PJSIR, 43(1), 50–54. Retrieved from http://v2.pjsir.org/index.php/biological-sciences/article/view/1993

Issue

Vol. 43 No. 1 (2000): Pakistan Journal of Scientific and Industrial Research

Section

Articles