?POTENTIAL ANTIBACTERIAL AGENTS PART-V. SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF SOME NEW 3-ARYL 7H, 6-(ARYL) SH-l, 2, 4-TRIAZOLO [3, 4-b]-1, 3, S-THIADIAZINES

Authors

  • Tahira B Sarfrazt Pharmaceutical and Fine Chemicals Research Centre, PCSIR Laboratories Complex, Karachi-75280, Pakistan
  • Shaheen A Husain Pharmaceutical and Fine Chemicals Research Centre, PCSIR Laboratories Complex, Karachi-75280, Pakistan
  • Najma Murtaza Pharmaceutical and Fine Chemicals Research Centre, PCSIR Laboratories Complex, Karachi-75280, Pakistan
  • Billa S Slddlqui H E J Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan

Keywords:

Fused ring heterocyclic compounds, Triazolothiadiazines, Intramolecular Mannich condensation.

Abstract

N-(Substituted benzoyl) thiosernicarbazides lla-e were treated with sodium hydroxide solution to give 3-aryl-S- e
mercapto-4H-i ,2,4-triazolc 111a-e which were subjected to Mannich Reaction in presence of2-0Cll;, 4-NOz and 2-
OeH) substituted anilines to give 3-aryl 7H, 6-(aryl) SH-I,2,4-triazolo [3,4-b]-I,3,S-thiadiazines IVa-h. The com-
pounds, IVa-h were compared with oxytetracycline and ampiclox (standard antibiotics) for their antibacterial activity.

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Published

2000-12-18

How to Cite

Sarfrazt, T. B., Husain, S. A., Murtaza, N., & Slddlqui, B. S. (2000). ?POTENTIAL ANTIBACTERIAL AGENTS PART-V. SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF SOME NEW 3-ARYL 7H, 6-(ARYL) SH-l, 2, 4-TRIAZOLO [3, 4-b]-1, 3, S-THIADIAZINES. Biological Sciences - PJSIR, 43(6), 334–337. Retrieved from http://v2.pjsir.org/index.php/biological-sciences/article/view/2063

Issue

Vol. 43 No. 6 (2000): Pakistan Journal of Scientific and Industrial Research

Section

Articles