Study of Histo-curative Potential of Jambul (Syzygium cumini) Fruit Pulp Extract in Mice Kidney Under Chromic Lead (Pb) Exposure

Study of Histo-curative Potential of Jambul at Mice

Authors

  • lram lnayat Department of Zoology, University of Sargodha, Sargodha, Pakistan
  • Syeda Nadia Ahmad, Department of Zoology, University of Sargodha, Sargodha, Pakistan
  • Sadia Suleman Department of Zoology, University of Sargodha, Sargodha, Pakistan
  • Saira Siddique Department of Zoology, University of Sargodha, Sargodha, Pakistan
  • Rabiya Ali Department of Zoology, University of Sargodha, Sargodha, Pakistan
  • Sitara Shameem Department of Zoology, University of Sargodha, Sargodha, Pakistan
  • Asma Younis Department of Zoology, University of Sargodha, Sargodha, Pakistan
  • Aima lram Batool Department of Zoology, University of Sargodha, Sargodha, Pakistan
  • Muhammad Ali Kanwal Department of Zoology, University of Sargodha, Sargodha, Pakistan
  • lram Zulfiqar Department of Zoology, University of Sargodha, Sargodha, Pakistan
  • Khawaja Raees Ahmad Department of Zoology, University of Sargodha, Sargodha, Pakistan

Keywords:

histo-curative, Syzygium cumini, kidney, renal histopathology, lead

Abstract

Lead oral exposure related pathological changes in kidneys and their ameliorations through Jambul Fruit Pulp Extract (JFPE) treatment were investigated in Albino Laboratory Mice. Adult male animals (n=30) weighing an average of 30 g were equally distributed into three groups, control (no treatment), lead (Pb) group (50 ppm Pb ions from lead acetate were given in drinking water 15 days+Pb ions free water 5 days) and Pb-J (lead+Jambul) group (50 ppm Pb ions as in Pb group+Jambul pulp extract 0.2 mL from 16-20 days). All animals were euthanized to recover kidneys for histopathological study on day 21. Results showed Pb exposure related significant decline in kidney and animal body weights. Histopathological findings were shrinkage of glomeruli and the proximal tubules, whereas the micrometric data indicated significant decline in glomerular size (2233.91±47.9 µm2) CSA (cross sectional area) of tubule size (561.0±23.4 µm2), caliber (97.9±7.2 µ2), wall thickness (462.0±22.8 µ2) and number of glomeruli per unit area (1.56±0.2) in Pb group. All these weight parameters, histopathological signs and micrometric observations indicate very good signs of recovery from such pathological changes in Pb-J group. These findings clearly show the importance of JFPE towards rehabilitation of the functional micro-architecture of the kidneys after Pb ion exposure related damage.

 

 

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Published

2022-10-20

How to Cite

lram lnayat, Syeda Nadia Ahmad, Sadia Suleman, Saira Siddique, Rabiya Ali, Sitara Shameem, Asma Younis, Aima lram Batool, Muhammad Ali Kanwal, lram Zulfiqar, & Khawaja Raees Ahmad. (2022). Study of Histo-curative Potential of Jambul (Syzygium cumini) Fruit Pulp Extract in Mice Kidney Under Chromic Lead (Pb) Exposure: Study of Histo-curative Potential of Jambul at Mice. Biological Sciences - PJSIR, 65(3), 222–227. Retrieved from http://v2.pjsir.org/index.php/biological-sciences/article/view/2980