Biological Evaluation of Extracts and Triterpenoids of Euphorbia hirta

Authors

  • M. Abu- Sayeed Department of Applied Chemistry and Chemical Technology, Rajshahi University, Rajshahi-6205, Bangladesh
  • M. Abbas Alib, Department of Chemistry, Rajshahi University of Engineering and Technology, Rajshahi-6204, Bangladesh
  • P.K. Bhattacharjeeb , Department of Chemistry, Rajshahi University of Engineering and Technology, Rajshahi-6204, Bangladesh
  • Anwarul Islamb Department of Chemistry, Rajshahi University of Engineering and Technology, Rajshahi-6204, Bangladesh
  • G.R.M. Astaqb Department of Chemistry, Rajshahi University of Engineering and Technology, Rajshahi-6204, Bangladesh

Keywords:

: Euphorbia hirta, triterpenoids, brine shrimp lethality bioassay, antibacterial activity, antifungal activity, taraxerone, 11,12 -oxidotaraxerol

Abstract

Antibacterial and antifungal activities of crude extracts and two triterpenoids, taraxerone (EH-1) and 11a, 12a- oxidotaraxerol (EH-2) isolated from the plant Euphorbia hirta were tested against fourteen pathogenic bacteria and six fungi. Crude extracts and pure compounds exhibited significant activity against most of the bacteria tested. On the other hand, all the crude extracts and pure compounds were active, but not significant enough, against most of the tested fungi. The minimum inhibitory concentrations (MICs) of the isolated compounds were also determined against the tested organisms (107 cells/ml) and the effective values were found to be between 64-128 mg/ml. In the brine shrimp lethality bioassay, the compounds were screened for their probable cytotoxic activity, and the LC values of EH-1 and EH-2 were found to be 17.78 and 10 mg/ml, respectively

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Published

2005-04-25

How to Cite

Sayeed, M. A.-., Alib, M. A., Bhattacharjeeb, P., Islamb, A., & Astaqb, G. (2005). Biological Evaluation of Extracts and Triterpenoids of Euphorbia hirta. Biological Sciences - PJSIR, 48(2), 112–125. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/1356