COLORIMETRIC DETERMINATION OF PARACETAMOL IN RAW MATERIAL AND IN PHARMACEUTICAL DOSAGE FORMS

Authors

  • C O Usifoh Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
  • S A Adelusi Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
  • R F Adebambo Department of ChemistrJ J, Ondo State University, Ado-Ekiti , Nigeria

Keywords:

: Paracetamol , Phannaceutical dosage forms, P-dimethylaminobenzaldeh yde.

Abstract

A rapid , accurate and simple method is proposed for the determination of p-acetaminophen (paracetamol) in raw material, tablets and syrups. The method is based on measuring the i ntensity of the yellow color that developed when acute acetaminophen is allowed to react with p-dimethylaminobenzaldehyde in 2M I-IC! after heating.

The color which absorbs in  the visible region  oft,450nm  is stable for several hours and the intensity is directly proportional  to the concentration of the drug, that is, Beer-lambert law is obeyed. The method can be used to analyse paracetamol in raw material  and in pharmaceutic al dosage forms.

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Published

2002-02-18

How to Cite

Usifoh, C. O., Adelusi, S. A., & Adebambo, R. F. (2002). COLORIMETRIC DETERMINATION OF PARACETAMOL IN RAW MATERIAL AND IN PHARMACEUTICAL DOSAGE FORMS. Biological Sciences - PJSIR, 45(1), 7–9. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/1729

Issue

Vol. 45 No. 1 (2002): Pakistan Journal of Scientific and Industrial Research

Section

Articles