Abdel-Ghany A EI-Helby Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt

Abstract

The potassium salts of N-substituted anthranilic acid (I) were allowed to react with Nt-chloroacetylsulfonamides (II),
to give substitutedaminosulfamoylphenylaminocarbonylmethyl,N-substitutedanthranilicacid esters (III). The structure
of the produced ester (III) were confirmed by microanalytical and spectral data. Preliminary pharmacological testing
of the new esters showed that, some derivatives were found to possess marked antipyretic, analgesic and antispasmodic
activities compared with paracetamol and atropine as reference drugs.