Synthesis and Characterization of Valero and Isovalero Hydroxamic Acids and their Complexes with Zn(II) And Al(III)

Synthesis of Valero and Isovalero Hydroxamic Acids

Authors

  • H. D. Aliyu Department of Chemistry, University of Abuja, P.M.B. 117, Abuja, Nigeria
  • J. N. Nwabueze Department of Chemistry, University of Abuja, P.M.B. 117, Abuja, Nigeria

Keywords:

hydroxamic acid, matrix metalloproteases, zinc, aluminum, valerohydroxamic acid

Abstract

 

Valerohydroxamic acid (VAH) and isovalerohydroxamic acid (IVAH) were synthesized and characterized by m.p. and pKa determination, IR and 1H NMR studies. The ligands were complexed with Zn2+ and Al3+ and the complexes were characterized by metal analysis, IR and conductance studies. Antimicrobial studies of all the com- pounds were carried out. The pKa of the ligands are 9.50 ± 0.01 (VAH) and 9.51± 0.01 (IVAH) at 25 °C and ionic strength is 0.1 mol/dm3, while their melting points are 77.8 °C and 76.8 °C, respectively. IR and 1H NMR data are consistent with the proposed formula. The complexes are non-electrolytes in EtOH. Coordination mode (0,0) is consis- tent with the IR data of the complexes. The compounds exhibited no significant antimicrobial activity.

 

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Published

2009-10-26

How to Cite

Aliyu, H. D., & Nwabueze, J. N. (2009). Synthesis and Characterization of Valero and Isovalero Hydroxamic Acids and their Complexes with Zn(II) And Al(III): Synthesis of Valero and Isovalero Hydroxamic Acids. Biological Sciences - PJSIR, 52(5), 239–242. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/555

Issue

Vol. 52 No. 5 (2009): Pakistan Journal of Scientific and Industrial Research

Section

Articles