Evaluation of Five Indigenous Medicinal Plants of Sindh, Pakistan for their Antifungal Potential

Antifungal Potential of Some Medicinal Plants

Authors

  • Erum Naz Department of Microbiology, University of Karachi, Karachi-75270, Pakistan
  • Mansoor Ahmad Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi-75270, Pakistan

Keywords:

mycosis, candidiasis, Trachyspermum ammi, Hyoscyamus niger, Carum roxburgianum, Linum usitatissimum, Centella asiatica, filamentous fungi

Abstract

Candidiasis and systemic mycosis due to opportunistic pathogens is frequently reported in Sindh, especially in rural areas. In search of local antifungal medicinal plants, methanol, petroleum ether and aqueous extracts of five native medicinal plants Trachyspermum ammi, Hyoscyamus niger, Carum roxburgianum, Linum usitatissimum and Centella asiatica were screened against five Candida strains including three strains of Candida albicans and one strain of C. glabrata and C. tropicalis, each. Antimicrobial screening of five filamentous fungal strains of clinical origin comprising of three strains of Aspergillus niger, one species of A. flavus and Penicillium each, revealed 100% activity of methanolic extract of ammi; petroleum ether extract of T. ammi and H. niger and methanolic extracts of H. niger, C. asiatica and C. roxburgianum produced 60, 20, 50, 50 and 10% inhibition, respectively, whereas, L. usitatissimum was inactive. Reference antibiotics were Nystatin and Amphotericin-B for yeast species and filamentous fungi, respectively. Least minimum inhibitory concentration (125 mg/disc) against Candida sp. was produced by the methanolic extract of T. ammi and H. niger and 500 and 1000 mg/disc against Aspergillus species, respectively. Results indicated that T. ammi and H. niger may be considered as potential future antifungal agents.

 

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Published

2009-12-28

How to Cite

Naz, E., & Ahmad, M. (2009). Evaluation of Five Indigenous Medicinal Plants of Sindh, Pakistan for their Antifungal Potential: Antifungal Potential of Some Medicinal Plants. Biological Sciences - PJSIR, 52(6), 328–333. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/579