Comparative Efficacy of Some Quinolones and Doxycycline Against Chronic Infection of Brucella melitensis 16M in BALB/c Mice

Treatment Methods for Brucella melitensis Infection

Authors

  • Mazen Safi Department of Molecular Biology and Biotechnology, Atomic Energy Commission, P.O. Box 6091, Damascus, Syria
  • Bassam Albalaa Department of Molecular Biology and Biotechnology, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria
  • Nermen Haj Mahmoud Department of Molecular Biology and Biotechnology, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria
  • Ayman Al-Mariri Department of Molecular Biology and Biotechnology, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria

DOI:

https://doi.org/10.52763/PJSIR.BIOL.SCI.59.2.2016.75.79

Keywords:

doxycycline, quinolones, Brucella melitensis, BALB/c mice

Abstract

This study was under taken to observe various treatment methods for brucellosis caused by
Brucella melitensis. The effect of therapeutic regimens with ciprofloxacin, ofloxacin and levofloxacin
alone or in combination with doxycycline was assessed against B. melitensis chronic infection using
200 mice. Doxycycline alone or in combination with ciprofloxacin was significantly found to reduce the
infection till 135 days post-infection (p<0.0001). Moreover, doxycycline was more effective than ciprofloxacin
and ofloxacin 135 days post-infection (p = 0.04 and p = 0.02, respectively). However, treatment with
quinolone-doxycycline combinations revealed synergistic effects as they were able to reduce the splenic
cell forming unit (CFU) from day 45 post-infection. Similarly, doxycycline treatment reduced the splenic
colony forming unit (CFU) from day 90 post-infection. In conclusion, doxycycline seems to be the most
effective agent against Brucella chronic infection.

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Published

2016-08-24

How to Cite

Safi, M., Albalaa, B., Mahmoud, N. H., & Al-Mariri, A. (2016). Comparative Efficacy of Some Quinolones and Doxycycline Against Chronic Infection of Brucella melitensis 16M in BALB/c Mice: Treatment Methods for Brucella melitensis Infection. Biological Sciences - PJSIR, 59(2), 75–79. https://doi.org/10.52763/PJSIR.BIOL.SCI.59.2.2016.75.79

Issue

Vol. 59 No. 2 (2016): Pakistan Journal of Scientific and Industrial Research Series B: Biological Sciences

Section

Articles