Synthesis and Antimicrobial Activity of Some Heterocycles: Part-V

Authors

  • M. M. H. Bhuiyan Department of Chemistry, University of Chittagong-4331, Bangladesh
  • Khandker M. M. Rahman Department of Chemistry, University of Chittagong-4331, Bangladesh
  • M. K. Hossain Department of Chemistry, University of Chittagong-4331, Bangladesh
  • M. A. Rahim Department of Chemistry, University of Chittagong-4331, Bangladesh

Keywords:

: ethoxymethylenemalononitrile, pyrazolo[3,4-d]pyrimidine, antimicrobial activity, synthesis of heterocycles

Abstract

Ortho-aminonitrile (1) was prepared from ethoxymethylenemalononitrile. 4-Allylamino-1-methyl-6- methylthiopyrazolo[3,4-d]pyrimidine (4) was prepared by an initial treatment of compound (1) with carbon disulfide in pyridine followed by methylation with methyl iodide and subsequent reaction with allylamine in acetonitrile. Ortho- aminoester (5) was prepared from ethyl (ethoxymethylene) cyanoacetate. Reaction of compound (5) with formamide yielded compound (6), which was then tosylated. All compounds were screened for their antibacterial and antifungal activities.

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Published

2005-10-24

How to Cite

Bhuiyan, M. M. H., Rahman, K. M. M., Hossain, M. K., & Rahim, M. A. (2005). Synthesis and Antimicrobial Activity of Some Heterocycles: Part-V. Biological Sciences - PJSIR, 48(5), 318–321. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/1407

Issue

Vol. 48 No. 5 (2005): Pakistan Journal of Scientific and Industrial Research

Section

Articles