SYNTHESIS OF SOME NEW PYRIMIDINE DERIVATIVES INCORPORATED INTO OTHER HETEROCYCLES FOR BIOLOGICAL EVALUATION

Abstract

Chloroacetyl pyrimidine was synthesized and reacted  with  both  aromatic  amines  and  hydrazine  hydrate.  Hydrazide was reacted with !3-dicarbonyl compounds and also with different acid anhydrides. 2-Amino-pyrimidine afforded new Schiff 's bases which were cyclized with thioglycolic acid and thiolactic acid . Thiosemicarbazido derivatives  were cyclized to give thiadiazole which gave Mannich bases. Some of the  newly  prepared  compounds  were  biologically tested  as antimicrobials