SYNTHESIS AND ANTICONVULSANT ACTIVITY OF 2-SUBSTITUTED-5-CHLOROBEN­ ZOXAZOLE

Authors

  • Abdel- Ghany Department of Pharmaceutical Chemistry, Faculty of PharmacJ Al-Azhar University, Nasr City, Cairo, Egypt.
  • A EL- Helby Department of Pharmaceutical Chemistry, Faculty of PharmacJ Al-Azhar University, Nasr City, Cairo, Egypt.

Keywords:

: Anticonvulsant activity, Alkylchloroacetate, Hydrazine hydrate.

Abstract

The  potassium   salt(l)  of  5-chlorobenzoxazole-2-thione  was  prepared  and  allowed  to  react with  alkyl  chloroacetate and

 

alkyl  3-chloro-propiona te  to  afford  ll _

12

 

1 10

 

.Compound 11

2

 

was  allowed  to  react  with a mmonia  and  hydrazine hydrate to

 

11

 

afford 111

 

and  III

 

respecti vely.  The compound 111

12

 

was  also  reacted  with  the  appropiate  aldehydes  to  afford com­

 

13

 

pound s N _ w  The potassium  salt(l)  was  also  reacted  with  chloro-acetanilides  to  afford  compound s V

 

20_39

 

.   Preliminary

 

pharmacologi cal testing of some of these compounds showed that they exhibit anticonvulsant activity. The structu re of  these compound s was  confirmed  by elemental  analysis JR, 1HNMR  and  in  some cases by MS  spectral  data .

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Published

2002-08-26

How to Cite

Ghany, A.-., & Helby, A. E.-. (2002). SYNTHESIS AND ANTICONVULSANT ACTIVITY OF 2-SUBSTITUTED-5-CHLOROBEN­ ZOXAZOLE. Biological Sciences - PJSIR, 45(4), 219–225. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/1793

Issue

Vol. 45 No. 4 (2002): Pakistan Journal of Scientific and Industrial Research

Section

Articles