ACUTE TOXICOLOGICAL EvALUATION OF THE AQUEOUS EXTRACT OF ECLIPTA ALBA HAssK

Authors

  • Naseem M Qadri Pharmaceutical & Fine Chemical Research Centre, PCSIR Laboratories Complex, Karachi -75280, Pakistan
  • Shahnaz Ahmad Pharmaceutical & Fine Chemical Research Centre, PCSIR Laboratories Complex, Karachi -75280, Pakistan
  • Shamim Qureshi Pharmaceutical & Fine Chemical Research Centre, PCSIR Laboratories Complex, Karachi -75280, Pakistan
  • Yasmeen Badar Pharmaceutical & Fine Chemical Research Centre, PCSIR Laboratories Complex, Karachi -75280, Pakistan

Keywords:

Eclipta alba Hassk ., Toxicity study, E pro strata, Compositae.

Abstract

Acute toxicological evaluation of Eclipta alba, Hassk, was carried out on albino mice through oral, parenteral and systemic routes. The severity and depth of toxicities exhibited by either route were found to be dose dependent. The aqueous extract of E alba exhibited a marked action on the central nervous system. LD50 as calcul ated for oral, intrave­

nous and intraperitoneal routes were 7.841 g kg·1, 302.8 and 328.3 mg kg·1 respectively . An aqueous extract of E. alba                                                                                                                                                                                                                                  

was found to be safe and non-toxic  at a dose of 2.0 g kg·1   for oral and 200 mg kg·1 for intravenous  and intraperitoneal

routes.

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Published

2001-02-19

How to Cite

Qadri, N. M., Ahmad, S., Qureshi, S., & Badar, Y. (2001). ACUTE TOXICOLOGICAL EvALUATION OF THE AQUEOUS EXTRACT OF ECLIPTA ALBA HAssK. Biological Sciences - PJSIR, 44(1), 38–41. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/1870

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