?COLORIMETRIC DETERMINATION OF MEFLOQUINE IN BIOLOGICAL FLUIDS AND PHARMACEUTICAL DOSAGE FORMS

Authors

  • S.A ADELUSI Departmentof Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
  • A.O. ONYEKWELI Departmentof Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria

Keywords:

Mefloquine, Biologicailluid, Tablets and capsules.

Abstract

A rapid, accurate and simple colorimetric method is proposed for the determination of melloquine in biological
fluids and pharmaceutical dosage forms. The green complex (soluble in nitrobenzene) formed between melloquine
and cobalt/thiocyanate reagent has absorption maximum at 625nm. The percentage recoveries of 98-10I% obtained
in urine, plasma and serum and the limit of sensitivity of 0.1 ug/rnl showed that the method is applicable to the
determination of metloquine in these biological tluids. The method also gave a percentage label strength of 98% for
formulated mefloquine tablets and capsules.

Published

1996-02-19

Issue

Vol. 39 No. 1-4 (1996): Pakistan Journal of Scientific and Industrial Research

Section

Articles

How to Cite

?COLORIMETRIC DETERMINATION OF MEFLOQUINE IN BIOLOGICAL FLUIDS AND PHARMACEUTICAL DOSAGE FORMS. (1996). Biological Sciences - PJSIR, 39(1-4), 22-24. https://v2.pjsir.org/index.php/biological-sciences/article/view/2359