?CONVERSION OF 2-METHYLCHROMONES TO PYRIMIDINE DERIVATIVES

Abstract

2-Methylchromones Ja-d were converted to 4-methyl-6-(substituted phenyl) -2-[1 H]-thiopyrimidines IIa-d, via
the condensation with thiourea. These thiopyrimidines were converted to other pyrimidine derivatives e.g. bis
pyrimidinyl disulphides, oxopyrimidines, ethoxycarbonylmethylmercaptopyrimidines, ethoxycarbonylmethyl-
mercaptopyrimidine acid hydrazides, triazolylpyrimidines, pyrimidin-2-ylmercaptoacetyl-thiosemicarbazides and
dimethyl oxalacetate 2-carboxymethyl-mercaptopyrimidine acid hydrazides.