?SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1-(4-METHYL-2-0XO-2H-I-BENZOJlYRAN- 7-YLOXOACETYL)-4-ALKYLTHIOSEMICARBAZIDES; 1,3,4-THIADIAZOLES AND 1,2,4-TRIAZOLES.

Authors

  • S.H. ELTAMANY Chemistry Department, Faculty ofScience, Sue: Canol University. lsmailia, Egyp!
  • I.M. EL- DEEN Chemistry Department, Faculty ofScience, Sue: Canol University. lsmailia, Egyp!
  • M.E.ABDEI.- FATTAII Chemistry Department, Faculty ofScience, Sue: Canol University. lsmailia, Egyp!

Keywords:

Substituted I.JA-Thiadiazoles. 1.2.4-Triazolcs. Biological activity.

Abstract

A series of 1-(4-methyl-2-o"o-211-I-benzopyran-7-ylo:\oacetyl )-4-alkylthiosemicarbazides. S-triazo\cs and their
methyl derivatives has been synthesized by condensation of 4-methyl-2-oxo-211-I-bellzopyran-7-ylo"o-acctyl hydra-
zinc with alkyl isothiocyauatcs. Subcqucnt ring closure of the substituted thioscmicarbazidcs yielded the S-trial.Olcs.
and reaction with methyl iodide gave the corresponding methyl derivatives. The substituted I.J.4-thiadiazolcs have
been synthesized by cyclodchydration of the substituted thioscmicarhazidcs with phosphoric acid. The biological
activity of some new compounds is reported.

Published

1995-05-22

How to Cite

ELTAMANY, S., DEEN, I. E.-., & FATTAII, M.-. (1995). ?SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1-(4-METHYL-2-0XO-2H-I-BENZOJlYRAN- 7-YLOXOACETYL)-4-ALKYLTHIOSEMICARBAZIDES; 1,3,4-THIADIAZOLES AND 1,2,4-TRIAZOLES. Biological Sciences - PJSIR, 38(3-4), 115–118. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/2449

Issue

Vol. 38 No. 3-4 (1995): Pakistan Journal of Scientific and Industrial Research

Section

Articles