?ENHANCEMENT OF BRAIN REGIONAL TRYPTOPHAN CONCENTRATION FOLLOWING ADMINISTRATION OF DIAZEPAM: A DOSE RELATED STUDY

Authors

  • FARHAT BATOOL Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Laboratory. University of Karachi, Karachi-75270, Pakistan
  • TAHIRA PARVEEN Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Laboratory. University of Karachi, Karachi-75270, Pakistan
  • DARAKHSHANJ HALEEM Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Laboratory. University of Karachi, Karachi-75270, Pakistan

Keywords:

Diazepam, Tryptophan. Serotonin.

Abstract

Administration of diazepam at doses of 1,3 and 5 mg/kg attenuated home cage activity and open field activity of
rats. Plasma concentrations of total tryptophan decreased and those of free tryptophan increased in diazepam injected
rats. The concentration of tryptophan increased in the hypothalamus. striatum and cortex but not in the brain stem of
diazepam injected rats. The increases in the hippocampus were only marginal and occurred at high doses of the drug.
The possible mechanism for the increased availability of tryptophan to the brain and decreased serotonin turnover
reported in diazepam injected rats is discussed.

Published

1995-08-21

How to Cite

BATOOL, F., PARVEEN, T., & HALEEM, D. (1995). ?ENHANCEMENT OF BRAIN REGIONAL TRYPTOPHAN CONCENTRATION FOLLOWING ADMINISTRATION OF DIAZEPAM: A DOSE RELATED STUDY. Biological Sciences - PJSIR, 38(7), 267–270. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/2494

Issue

Vol. 38 No. 7 (1995): Pakistan Journal of Scientific and Industrial Research

Section

Articles