?SYNTHESIS, AN'FIMICROBIAL AND ANTIAFLATOXIGENIC ACTIVITIES OF SOME BENZOFURAN CONTAINING 1,2,4-TRIAZOLE, 1,3,4-THIADIAZOLE AND OXADIAZOLE DERIVATIVES

Authors

  • A. H. MANDOUR National Research Centre, Dokki, Cairo, Egypt
  • N. M. FAWZY National Research Centre, Dokki, Cairo, Egypt
  • T. H. EL- SHIHI National Research Centre, Dokki, Cairo, Egypt
  • Z. E.EL- BAZZA National Research Centre, Dokki, Cairo, Egypt

Keywords:

Xanthotoxin-4-sulfonamides, Benzofuranderivatives, 1,2,4-Triazole; 1,3,4-Thiadiazole, Oxadiazole

Abstract

Alkaline hydrolysis of 9-methoxypsoralene-4-sulfonamide derivatives (Ia-d) using potassium hydroxide and
dimethyl sulfate, afforded 3-propenoic acid derivative (IIa-d) which inturn were converted to 3-propenoic acid chlo-
ride (IlIa-d) by the action of thionyl chloride in boiling toluene. Condensation of the latter compounds with
thiosemicarbazide gave the corresponding carbonyl thiosemicarbazide derivatives (IVa-d). Cyclization of the latter
compounds using boiling 5% sodium hydroxide solution gave 5-mercapto-I,2,4-triazolyl-3 derivatives (Va-d), using
O-phosphoric acid gave 5-amino-I,3, 4-thiadiazolyl-3-derivatives (VIa-d) and using DCC gave 5-amino-l, 3, 4-
oxadiazolyl-2-derivatives (VIla-d), respectively. Also,theantimicrobialand antiaflatoxigenicactivities ofcompounds
(Va-d), (VIa-d) and (VIla-d) were investigated.

Published

1995-12-18

How to Cite

MANDOUR, A. H., FAWZY, N. M., SHIHI, T. H. E.-., & BAZZA, Z. E.-. (1995). ?SYNTHESIS, AN’FIMICROBIAL AND ANTIAFLATOXIGENIC ACTIVITIES OF SOME BENZOFURAN CONTAINING 1,2,4-TRIAZOLE, 1,3,4-THIADIAZOLE AND OXADIAZOLE DERIVATIVES. Biological Sciences - PJSIR, 38(11-12), 402–406. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/2532

Issue

Vol. 38 No. 11-12 (1995): Pakistan Journal of Scientific and Industrial Research

Section

Articles