Metabolic Inhibitors as Stimulating Factors for Citric Acid Production

Authors

  • Nehad Z. Adham * Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Cairo, Egypt
  • Essam M. Ahmed Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Cairo,
  • Heba A. El Refai Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Cairo, Egypt

Keywords:

citric acid, cane molasses, surface culture, metabolic inhibitor, Aspergillus niger

Abstract

The effect of some metabolic inhibitors on citric acid (CA) production by Aspergillus niger in cane molasses medium was investigated. Addition of 0.01-0.1 mM iodoacetic acid and sodium arsenate, 0.05-1.0 mM sodium malonate,0.01 mM sodium azide, 0.01-0.05 mM sodium fluoride, 0.1-1.0 mM EDTA stimulated CA production (5-49%). Higher concentrations (10 mM) of iodoacetic acid, sodium malonate and 0.5 mM sodium azide caused a complete inhibition of fungal growth. Iodoacetic acid, sodium arsenate and sodium fluoride (0.2 mM) caused a remarkable inhibition of CA production. The implications of those preliminary functions was discussed.

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Published

2008-01-24

How to Cite

Adham, N. Z., Ahmed, E. M., & Refai, H. A. E. (2008). Metabolic Inhibitors as Stimulating Factors for Citric Acid Production. Biological Sciences - PJSIR, 51(5), 245–249. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/680

Issue

Vol. 51 No. 5 (2008): Pakistan Journal of Scientific and Industrial Research

Section

Articles