?DISSOCIATION EXTRACTION PROCESS FOR THE SEPARATION OF ISOMERIC ORGANIC COMPOUNDS
Keywords:
Dissociation extraction, Separation factor, Dissociation constants.Abstract
Separation of mixture of isomeric organic compound was achieved by exploiting the difference in their dissociation
constants by employing dissociation extraction technique. Mixture of 3-picoline and 4-picoline was partially separated
with sodium dihydrogen phosphate to demonstrate the phenomenon of dissociation extraction. A theoretical treatment of
separation of isomers is given which can be utilized to predict the separation factor of dissociated and undissociated species
of isomers. Increase in temperature had a positive influence on the separation of isomers and also on the phase disengagement
between the aqueous and the organic phases. A process is described to develop a suitable chemical material bed in the
column for gas-liquid chromatograph that reduces the retention time and gives high resolution of picolines.