?SYNTHESIS AND CARDIOVASCULAR ACTIVITY OF NEW PHENOTHIAZINES

Authors

  • ASHOK KUMAR Department of Pharmacology and Pharmacy, L. L. R. M. Medical College, Meeru!-250004 (U.P.), India
  • R S VERMA Department of Pharmacology and Pharmacy, L. L. R. M. Medical College, Meeru!-250004 (U.P.), India
  • S K BHATIA Department of Pharmacology and Pharmacy, L. L. R. M. Medical College, Meeru!-250004 (U.P.), India
  • SWATI GUPTA Department of Pharmacology and Pharmacy, L. L. R. M. Medical College, Meeru!-250004 (U.P.), India
  • u K JETTL Department of Pharmacology and Pharmacy, L. L. R. M. Medical College, Meeru!-250004 (U.P.), India
  • V S K BAJPAI Department of Pharmacology and Pharmacy, L. L. R. M. Medical College, Meeru!-250004 (U.P.), India
  • K K SAXENAANDV Department of Pharmacology and Pharmacy, L. L. R. M. Medical College, Meeru!-250004 (U.P.), India
  • K SRIVASTAVA Department of Pharmacology and Pharmacy, L. L. R. M. Medical College, Meeru!-250004 (U.P.), India

Keywords:

Phenothiazine derivatives, Cardiovascular activity, Toxicity studies.

Abstract

Some new Schiffs bases substituted-benzaldehyde, 2-(2-acetyl-lOH-phenothiazin-I0-yl)-2-oxo-ethyl hydrazones
(Iva-IVe), 2-acetyl-l 0-(5-substituted phenyJ-2-oxo-4-thiazoJidin-I-yl)-aminoacetylphenothiazines (Va-ve), 2-acetyl-
I0-[(2-oxo-3-chloro-4-azetidin-l-yl) aminoacetylphenothiazines (VIa-VIe) and I, 3-disubstituted phenyl-5-[(2-acetyl-
1O-phenothiazin-I 0-yl)-2-oxo-ethyJ] formazans (Vlla-Vllb) have been synthesized and were evaluated for their car-
diovascular activity. Compounds Iv a, Ivd and IVe showed highly statistically significant changes in blood pressure,
heart rate and pressor responses (Cardiovascular activity). The most active compound in our preliminary study is
found to be 2, 4-dichlorobenzaldehyde 2-(2-acetyl-1 OH-phenothiazin-I0-yl)-2-oxo-ethyl hydrazone (IVa) which showed
statistically significant changes in the fall of blood pressure (75.63%).

Published

1996-02-19

How to Cite

KUMAR, A., VERMA, R. S., BHATIA, S. K., GUPTA, S., JETTL, u K., BAJPAI, V. S. K., SAXENAANDV, K. K., & SRIVASTAVA, K. (1996). ?SYNTHESIS AND CARDIOVASCULAR ACTIVITY OF NEW PHENOTHIAZINES. Biological Sciences - PJSIR, 39(1-4), 1–4. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/2354

Issue

Vol. 39 No. 1-4 (1996): Pakistan Journal of Scientific and Industrial Research

Section

Articles