Synthesis of Some New Substituted Quinazolin-4-3H-Ones as Potent Anticonvulsant Agents

Synthesis of New Quinazolinones

Authors

  • Ashok Kumar Medicinal Chemistry Division, Department of Pharmacology, LLRM Medical College, Meerut-250004 (U.P.), India
  • K. K. Saxena Medicinal Chemistry Division, Department of Pharmacology, LLRM Medical College, Meerut-250004 (U.P.), India
  • S. Lata Medicinal Chemistry Division, Department of Pharmacology, LLRM Medical College, Meerut-250004 (U.P.), India
  • Neha Garg Medicinal Chemistry Division, Department of Pharmacology, LLRM Medical College, Meerut-250004 (U.P.), India
  • Trilok Chandra Medicinal Chemistry Division, Department of Pharmacology, LLRM Medical College, Meerut-250004 (U.P.), India

Keywords:

benzylidenoquinazolinones, thiazolylquinazolinones, thiazolidinoylquinazolinone, anticonvulsant activity, toxicity

Abstract

A new series of 3-(4-(2-(6,8-dibromo-3-(substituted phenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl) hydrazinyl)thiazol-2-yl)-2-phenylthiazolidin-4-ones were synthesized and their structures were elucidated on the basis of elemental analyses and spectroscopic studies (IR, 1H-NMR). All the synthesized compounds 1-32 were screened for their anticonvulsant activity at a dose of 30 mg/kg. The compound 31 was found to be the most potent compound of this series showing 90% protection against  MES.

 

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Published

2009-02-23

How to Cite

Kumar, A., Saxena, K. K., Lata, S., Garg, N., & Chandra, T. (2009). Synthesis of Some New Substituted Quinazolin-4-3H-Ones as Potent Anticonvulsant Agents: Synthesis of New Quinazolinones. Biological Sciences - PJSIR, 52(1), 8–14. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/501

Issue

Vol. 52 No. 1 (2009): Pakistan Journal of Scientific and Industrial Research

Section

Articles