Potential Antibacterial Agents: Part VI- Synthesis and Structure Elucidation of Schiff Bases Derived from Hydralazine

Authors

  • Tahira B. Sarfaraz *, Fuel Research Centre, PCSIR Laboratories Complex, Karachi-75280, Pakistan
  • Naheed Sultana Pharmaceutical Research Centre, PCSIR Laboratories Complex, Karachi- 75280, Pakistan
  • Aisha Nelofar Pharmaceutical Research Centre, PCSIR Laboratories Complex, Karachi- 75280, Pakistan
  • Shaheen A. Hussain " Pharmaceutical Research Centre, PCSIR Laboratories Complex, Karachi- 75280, Pakistan

Keywords:

: hydrazone, triazole, anti bacterial acti vity, hydralazi ne, spectroscopic techniq ues

Abstract

Synthesis of h ydrazones (Schiff bases) of an antihypertensive drug, hydra lazi ne was carried out. The study afforded the h itherto u nrepo rted 1 -[4-ch l orobenzyl i dene]-hyd razi nophtha l azi ne (111-a ), 1 -[ben zyl ide ne]­ h ydrazinophthal azi ne ( I 11-b ) , 1 -[4-n i trobenzyl i dene]-hydrazi nophthal azi ne (I II-c ), 1 -[2-n i trobenzyl i dene]­ hydrazi nophthalazi ne (III-d), 3-[4-chlorophenyl]-s-triazolo [3-4-a] phthalazine (IV-a) and 3-phenyl-s-triazolo [3-4-a] phthalazi ne (IV-b). The structu res of these compounds were established usi ng spectroscopic techniques i.e. [R, UV, 'HN MR, EIMS, FD and HR MS. Antibacterial activity of the drugs was eval uated.

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Published

2007-06-26

How to Cite

Sarfaraz, T. B., Sultana, N., Nelofar, A., & Hussain, S. A. (2007). Potential Antibacterial Agents: Part VI- Synthesis and Structure Elucidation of Schiff Bases Derived from Hydralazine. Biological Sciences - PJSIR, 50(3), 169–172. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/859