?COMMERCIAL EXTRACTION AND RESOLUTION OF SILYMARIN ISOMERS

Authors

  • L Khan Medicinal Botanic Centre, PCSIR Laboratories Complex, Peshawar-25120, Pakistan
  • N Shafi Medicinal Botanic Centre, PCSIR Laboratories Complex, Peshawar-25120, Pakistan
  • S Farooq Medicinal Botanic Centre, PCSIR Laboratories Complex, Peshawar-25120, Pakistan
  • S N Gilani Medicinal Botanic Centre, PCSIR Laboratories Complex, Peshawar-25120, Pakistan
  • T Mahmood Medicinal Botanic Centre, PCSIR Laboratories Complex, Peshawar-25120, Pakistan
  • N Ahmad Medicinal Botanic Centre, PCSIR Laboratories Complex, Peshawar-25120, Pakistan

Keywords:

Silybum marianum seeds, Silymarin, Silybin, Silydianin, Silychristin.

Abstract

A simple and economical procedure for the large-scale extraction of silymarin from the dried seeds of Silybum marianum
has been developed. After harvest the cellular and acellular constituents of the seeds are biodegradable. Using the fresh
seeds, a viable procedure has been perfected for the extraction of silymarin (yield 1.47 %). The product appeared as a
mixture and was resolved into the isomers by centrifugal chromatography. The identity of the product and its isomers were confirmed through comparison with standards using mp, UV, IR, 1H NMR and Mass spectrometric data and 2,4,
dinitrophenylhydrazone assay.

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Published

2003-08-25

How to Cite

Khan, L., Shafi, N., Farooq, S., Gilani, S. N., Mahmood, T., & Ahmad, N. (2003). ?COMMERCIAL EXTRACTION AND RESOLUTION OF SILYMARIN ISOMERS. Biological Sciences - PJSIR, 46(4), 307–310. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/1656

Issue

Vol. 46 No. 4 (2003): Pakistan Journal of Scientific and Industrial Research

Section

Articles