INDUCTION ELICITATION OF CONTACT SENSITIVITY IN MICE DUE TO PROHAPTEN

Authors

  • L Khan Medicinal Botanic Centre, PCSJR Laboratories, Peshawar-25100, Pakistan h
  • R J Schmidt Welsh School of Pharmacy, UWCC, PO Box 13, Cardiff CF} 3XF, U K
  • S N Gilani Medicinal Botanic Centre, PCSJR Laboratories, Peshawar-25100, Pakistan h
  • N Shafi Medicinal Botanic Centre, PCSJR Laboratories, Peshawar-25100, Pakistan h
  • K D Ahmad Medicinal Botanic Centre, PCSJR Laboratories, Peshawar-25100, Pakistan h

Keywords:

: Prohapten, Partition coefficient, Amino acid conjugation, Contact sensitization

Abstract

The prohaptenic status of abietic  acid ,  meth ylabietate, 3-methylcholanthrene  (3-Mc), 3-pentadecylphenol  (3-PDP), and 5-pentadecylresorcinol (5-PDR), was confirmed by partition coefficient studies and  conjugation  reactions  with  amino acids. The sensitizing effects observed on mou se skin showed activation of prohapten into hapten during the induction  and  elicitation  of the  contact  sensitization reaction s.

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Published

2002-04-22

How to Cite

Khan, L., Schmidt, R. J., Gilani, S. N., Shafi, N., & Ahmad, K. D. (2002). INDUCTION ELICITATION OF CONTACT SENSITIVITY IN MICE DUE TO PROHAPTEN. Biological Sciences - PJSIR, 45(2), 97–101. Retrieved from https://v2.pjsir.org/index.php/biological-sciences/article/view/1762

Issue

Vol. 45 No. 2 (2002): Pakistan Journal of Scientific and Industrial Research

Section

Articles